The Correlation Between the Plasma Level of Endothelin-1 and Pulmonary Artery Pressure in Patients on Hemodialysis Due to End-Stage Renal Disease
Archives of Critical Care Medicine,
Vol. 1 No. 1 (2015),
21 October 2023
Abstract
Background: Chronic kidney disease, especially in patients with underlying pulmonary arterial hypertension (PAH), severely deteriorates
the patients' quality of life. Early diagnosis would help to improve the outcome.
Objectives: This study was performed to assess the association between the plasma level of endothelin-1 and the measured PAH in the
patients on hemodialysis due to end-stage renal disease.
Patients and Methods: In a descriptive, analytic, cross-sectional study, 40 patients were recruited. The pulmonary artery pressure (PAP)
was measured via echocardiography and its association with plasma endothelin-1 as well as CRP levels was assessed.
Results: There was a significant association between PAP and endothelin-1 (r = 0.93; P < 0.0001) as well as PAP and CRP (r = 0.893; P < 0.0001).
Conclusions: The study demonstrated that in patients with underlying kidney disease, pulmonary artery pressure is strongly associatedwith endothelin-1 levels as well as CRP.
- Endothelin-1
- Chronic Kidney Disease
- Artery; Pressure
How to Cite
References
Rosenblum WD. Pulmonary arterial hypertension: pathobiology, diagnosis, treatment, and emerging therapies. Cardiol Rev.
;18(2):58–63.
Abman SH. Pulmonary hypertension in children: a historical
overview. Pediatr Crit Care Med. 2010;11(2 Suppl):S4–9.
Oishi P, Datar SA, Fineman JR. Pediatric pulmonary arterial hypertension: current and emerging therapeutic options. Expert
Opin Pharmacother. 2011;12(12):1845–64.
Ventetuolo CE, Kawut SM, Lederer DJ. Plasma endothelin-1 and
vascular endothelial growth factor levels and their relationship
to hemodynamics in idiopathic pulmonary fibrosis. Respiration.
;84(4):299–305.
Yu J, Taylor L, Wilson J, Comhair S, Erzurum S, Polgar P. Altered
expression and signal transduction of endothelin-1 receptors in
heritable and idiopathic pulmonary arterial hypertension. J Cell
Physiol. 2013;228(2):322–9.
Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, et
al. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric
oxide levels and modulate pulmonary arterial hypertension. Circulation. 2012;126(8):963–74.
Rich S. Right ventricular adaptation and maladaptation
in chronic pulmonary arterial hypertension. Cardiol Clin.
;30(2):257–69.
Morin C, Fortin S, Rousseau E. Docosahexaenoic acid monoacylglyceride decreases endothelin-1 induced Ca(2+) sensitivity
and proliferation in human pulmonary arteries. Am J Hypertens.
;25(7):756–63.
Huang H, Zhang P, Wang Z, Tang F, Jiang Z. Activation of endothelin-1 receptor signaling pathways is associated with neointima
formation, neoangiogenesis and irreversible pulmonary artery
hypertension in patients with congenital heart disease. Circ J.
;75(6):1463–71.
Shao D, Park JE, Wort SJ. The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension. Pharmacol Res.
;63(6):504–11.
Pan P, Zhang X, Qian H, Shi W, Wang J, Bo Y, et al. Effects of electroacupuncture on endothelium-derived endothelin-1 and endothelial nitric oxide synthase of rats with hypoxia-induced pulmonary hypertension. Exp Biol Med (Maywood). 2010;235(5):642–8.
Hamidi SA, Lin RZ, Szema AM, Lyubsky S, Jiang YP, Said SI. VIP
and endothelin receptor antagonist: an effective combination
against experimental pulmonary arterial hypertension. Respir
Res. 2011;12:141.
Channick RN, Sitbon O, Barst RJ, Manes A, Rubin LJ. Endothelin
receptor antagonists in pulmonary arterial hypertension. J Am
Coll Cardiol. 2004;43(12 Suppl S):62S–7S.
Dupuis J, Jasmin JF, Prie S, Cernacek P. Importance of local
production of endothelin-1 and of the ET(B)Receptor in the
regulation of pulmonary vascular tone. Pulm Pharmacol Ther.
;13(3):135–40.
Yuan P, Wu WH, Gao L, Zheng ZQ , Liu D, Mei HY, et al. Oestradiol ameliorates monocrotaline pulmonary hypertension
via NO, prostacyclin and endothelin-1 pathways. Eur Respir J.
;41(5):1116–25
- Abstract Viewed: 7 times
- PDF Downloaded: 0 times