The Correlation Between the Plasma Level of Endothelin-1 and Pulmonary Artery Pressure in Patients on Hemodialysis Due to End-Stage Renal Disease
Archives of Critical Care Medicine,
Vol. 1 No. 1 (2015),
21 October 2023,
Background: Chronic kidney disease, especially in patients with underlying pulmonary arterial hypertension (PAH), severely deteriorates
the patients' quality of life. Early diagnosis would help to improve the outcome.
Objectives: This study was performed to assess the association between the plasma level of endothelin-1 and the measured PAH in the
patients on hemodialysis due to end-stage renal disease.
Patients and Methods: In a descriptive, analytic, cross-sectional study, 40 patients were recruited. The pulmonary artery pressure (PAP)
was measured via echocardiography and its association with plasma endothelin-1 as well as CRP levels was assessed.
Results: There was a significant association between PAP and endothelin-1 (r = 0.93; P < 0.0001) as well as PAP and CRP (r = 0.893; P < 0.0001).
Conclusions: The study demonstrated that in patients with underlying kidney disease, pulmonary artery pressure is strongly associatedwith endothelin-1 levels as well as CRP.