The Effect of Formulation Type on the Release of Benzoyl Peroxide from Microsponges Benzoyl peroxide release from microsponges
Iranian Journal of Pharmaceutical Sciences,
دوره 1 شماره 3 (2005),
1 July 2005
,
صفحه 131-142
https://doi.org/10.22037/ijps.v1.39487
چکیده
Benzoyl peroxide (BPO) is a first-line topical treatment in acne vulgaris, and it is superior to antibiotics, because the bacteria do not develop resistance to it. Skin irritation is a common side effect, and it has been shown that controlled release of BPO from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. Therefore, the purpose of the present investigation was to
prepare suitable controlled release formulations for BPO. This study examined whether the type of topical formulation (cream, gel and lotion) can affect the release behavior of BPO from microsponges. Benzoyl peroxide microparticles were prepared using an emulsion solvent diffusion method by adding an organic internal phase containing benzoyl peroxide, ethyl cellulose and dichloromethane into a stirring aqueous phase containing polyvinyl alcohol. The loading capacity of the drug content and the mean particle size of microparticles were determined. BPO microparticles were then incorporated into various formulations (creams, gels and lotions) for release studies. The micrograph of microsponges showed that they were spherical in shape and contained pores. It was shown that the drug:polymer ratio, stirring rate, volume of the dispersed phase influenced the particle size and drug release behavior of the formed microsponges and that the presence of emulsifier was essential for microsponge formation. The results showed that, generally, an increase in the ratio of drug:polymer resulted in a reduction in the release rate of BPO from microsponges which was attributed to a decrease in internal porosity of the microsponges. The release data showed that the highest release rate was obtained from lotions containing BPO microparticles and the lowest was obtained from cream formulations.
- Drug release
- Drug:polymer ratio
- Microsponge
- Particle size
- Porosity
ارجاع به مقاله
مراجع
[2] Lorenzetti OJ, Wernet T, Mcdonald Alcon T. Some comparisons of benzoyl peroxide formulations. J Soc Cosmet Chem 1977; 28: 533-49.
[3] Arabi H, Hashemi SA, Fooladi M. Microencapsulation of alloporinol by solvent evaporation and controlled release investigation of drugs. J Microencapsul 1996; 13: 527-36.
[4] Puranik PK, Manekar NC, Dorle AK. Preparation and evaluation of abietic acid microcapsules by a solvent evaporation technique. J Microencapsul 1992; 9: 425-35.
[5] Wester RC, Patel R, Nacht S, Leyden J, Melenders J, Maibach H. Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy. J Am Acad Derm 1991; 24: 720-6.
[6] Embil K, Nacht S. The Microsponges® delivery system (MDS): a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. J Microencapsul 1996; 13: 575-8.
[7] Rainer A, Bodmeier R. Encapsulation of water soluble drugs by a modified solvent evaporation method. J Microencapsul 1990; 7: 347-55.
[8] Mena P, Martinez AR, Gallardo V. A topical formulation: for benzoyl peroxide factors affecting release of benzoyl peroxide in topical formulations. Cosmetics and Toiletries 1994; 109: 75-80.
[9] Perumal D. Microencapsulation of ibuprofen and Eudragit® RS 100 by the emulsion solvent diffusion technique. Int J Pharm 2001; 218: 1-11.
[10] Barkai A, Pathak YV, Benita S. Polyacrylate (Eudragit Retard) microspheres for oral controlled release of nifedipine. I. Formulation design and process optimization. Drug Dev Ind Pharm 1990; 16: 2057-75.
[11] Pongpaibul Y, Price JC, Whitworth CW. Preparation and evaluation of controlled release indomethacin microspheres. Drug Dev Ind Pharm 1984; 10:1597-616.
[12] Kilicarslan M, Baykara T. The effect of the drug:polymer ratio on the properties of verapamil HCl loaded microsoheres. Int J Pharm 2003; 252: 99-109.
[13] Comolu T, Nonul N, Baykara T. Preparation and in vitro evaluation of modified release ketoprofen microspones. Il Farmaco 2003; 58: 101-6.
[14] Kim CK, Kim MJ, Oh KH. Prepartion and evaluation of sustained release microspheres of terbutaline sulfate. Int J Pharm 1994; 106: 213-9.
- چکیده مشاهده شده: 80 بار
- IJPS_Volume 1_Issue 3_Pages 131-142 (English) دانلود شده: 22 بار