The Effect of Atenolol on Thyroid Hormons in Subclinical Hyperthyroidism Effect of atenolol on thyroid hormons
Iranian Journal of Pharmaceutical Sciences,
Vol. 1 No. 4 (2005),
1 October 2005
,
Page 243-248
https://doi.org/10.22037/ijps.v1.39547
Abstract
This Study was performed to evaluate the effect of atenolol on the serum concentration of TT4 and TT3 in subclinical hyperthyroid patients. Due to the i n s u fficient information about the effect of atenolol on serum level of these hormones, the aim of this research was to shade some light on the subject. Fifteen subclinical hyperthyroid patients entered this study. Each patient received 100 mg/day atenolol. The serum concentration of atenolol, TT4 and TT3 were measured before starting the administration of the drug and on the first, third and seventh day after atenolol administration was started. The serum concentrations of TT4, but not TT3, on the third and seventh day were increased significantly in comparison to the baseline TT4. There was no correlation between plasma atenolol concentration and changes in TT4 and TT3.
- Atenolol
- Subclinical hyperthyroidism
- TT3
- TT4
How to Cite
References
[2] Gefnwr DL, Hershman JM. Beta adrenerg i c blockade for the treatment of hyperthyroidism. Am J Med 1992; 93: 61.
[3] Feely J, Peden N. Use of beta adrenoreceptor blocking drugs in hyperthyroidism. D ru g s 1984; 27: 425-46.
[4] Kallner G, Ljunggren JG, Tryselius M. The effect of propranolol on serum levels of T4, T3 and rT3 in hyperthyroidism. Acta Med Scand 1978; 204: 35-7.
[5] Lotti G, Delitala G, Devilla L, Alagna S, Masaiu A. Reduction of plasma T3 induced by propranolol. Clin Endocrinol (Oxf) 1977; 6: 405-10.
[6] Feber J, Friis T, Kirkegard C et al. Serum T4, T3 and rT3 during treatment with propranolol in hyperthyroidism, LT4 treated myxedema and in normal man. Hum Metab Res 1979; 11: 34-6.
[7] Wiersinga WM,Touber JL. The influence of beta adrenoreceptor blocking agents on plasma thyroxin and triidothyronine. J Clin Endocrinol 1977; 45:293-8.
[8] Harrower ADB, Fyfee JA, Horn DB, Strong JA. Thyroxine and triidothyronine levels in hyperthyroid patients during t reatment with propranolol. Clin Endocrin (Oxf) 1977; 7: 41-9.
[9] Nilsson OR, Melander A, Yegler L. Effects and plasma levels of propranolol and metoprolol in hyperthyroid patients. Eur J Clin Pharmacol 1980; 18: 315-20.
[10] McDevitt DJ, Nelson JK. Comprative trialsof atenolol and propranolol in hyperthyroidism. Br J Clin Pharmacol 1978; 6: 233-7.
[11] How J, Khir ASM, Bowsher PD. The effect of atenolol on serum thyroid hormones in hyperthyroid patients. Clin Endocrinol (Oxf) 1980; 13: 299-301.
[12] Nilsson OR, Karlberg BE, Kagedal B, Tegler L, Almqvist S. Nonselective and selective beta 1- adrenoceptor blocking agents in the treatment of hyperthyroidism. Acta Med Scand 1979; 206: 21-5.
[13] Shuklin BL, Peele ME, Utiger RD. Beta adrenergic antagonist inhibition of hepatic 3,5,3- triidothyronine production. Endocrinology 1984; 115: 858-61.
[14] Perrild H, Hanson JM, Skovsted L, Christensen LK. Different effects of propranolol, alpernolol, sotalol, atenolol and metoprolol on serum T3 and reverse T3 in hyperthyroidism. Clin Endocrinol (Oxf) 1983; 13: 139-42.
- Abstract Viewed: 56 times
- IJPS_Volume 1_Issue _Pages 243-248 Downloaded: 16 times