Effect of Nepeta glomerulosa Boiss. Aerial Parts Aqueous Extract on Morphine Withdrawal Syndrome in Mice Effect of Nepeta glomerulosa extract on morphine withdrawal syndrome
Iranian Journal of Pharmaceutical Sciences,
Vol. 2 No. 1 (2006),
15 Dey 2006
https://doi.org/10.22037/ijps.v2.39604
Abstract
The effect of aqueous extract of Nepata glomerulosa Boiss. aerial parts on morphine withdrawal syndrome was investigated in mice. Dependence was induced by subcutaneous injections of morphine for 3 consecutive days. On day 4, morphine was injected 2 h prior to intraperitoneal injection of naloxone. The number of jumps during a 20 min. period after naloxone injection was considered as a measure of the withdrawal syndrome. Open field and rotarod tests were also performed. The results indicated that the aqueous extract (0.1 to 2.8 g/kg, s.c.) and diazepam (5 mg/kg) reduced the number of jumps (58±2.3 to 10±0.82, p<0.001 vs normal saline, 87±3.4). The extracts also reduced motion balance and locomotion activity. It is concluded that the aqueous extract of N. glomerulosa aerial parts could diminish morphine withdrawal syndrome.
- Diazepam
- Morphine dependence
- Nepeta glomerulosa
- Withdrawal syndrome.
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References
[2] El Kadi AOS, Sharif SI. The influence of various experimental conditions on the expression of naloxone-induced withdrawal symptoms in mice. Gen Pharmacol 1994; 25: 1505-10.
[3] Kest B, Hopkins E, Palmese CA, Chen ZP, Mogil JS, Pintar JE. Morphine tolerance and dependence in nociceptin/orphanin FQ transgenic knock-out mice. Neuroscience 2001; 104: 217-22.
[4] Miyamoto Y, Takemori AE. Relative involvement of supraspinal and spinal mu opioid receptors in morphine dependence in mice. Life Sci 1993a; 52: 1039-44.
[5] Zafar S, Ahmad MA, Siddiqui TA. Protective role of Delphinium denudatum (yadwar) against morphine induced tolerance and dependence in mice. J Ethnopharmacol 2001; 78: 95-8.
[6] Bourin M, Malinge M, Colombel MC, Vasar E. Cholecystokinin receptor agonists block the jumping behavior precipitated in morphinedependent mice by naloxone. Eur Neuropsychopharmacol 1999; 9: 37-43.
[7] Aydin S, Demir T, Oztark Y, Baayer, KH. Analgesic activity of Nepeta italica L. Phytother Res 1999; 13: 20-3.
[8] Sonboli A, Salehi P, Yousefzadei M. Antimicrobial activity and chemical composition of the essential oil of Nepeta crispaWild. from Iran. Z Naturforsh C 2004; 59: 653-6.
[9] Aydin S, Beis R, Oztark Y, Baser KH, Baser C. Nepetalacton: A new opioid analgesic from Nepeta caesarea Boiss. J Pharm Pharmacol 1998; 50: 813-7.
[10] Ganzera M, Crockett S, Tellez MR, Khan IA. Determination of nepetalactose in Nepeta cataria by reversed phase high performance liquid chromatography. Pharmazi 2001; 56: 896-7.
[11] Fazly Bazzaz BS, Haririzadeh G, Imami SA, Rashed MH. Survey of Iranian plants for alkaloids, flavonoids, saponins, and tannins (Khorasan province). Int J Pharmacy 1997; 35: 17-30.
[12] Ebrahim Sajjadi S, Ghassemi N. Volatile constituents of Nepeta glomerulosa Boiss. subsp. carmanica. Flav Frag J 1999; 14: 265-7.
[13] Sefidkon F. Essential oil of Nepeta glomerulosa Bioss. from Iran. J Essent Oil Res 2001; 13:422-3.
[14] Hosseinzadeh H, Nourbakhsh M. Effect of Rosmarinus officinalis L. aerial parts extract on morphine withdrawal syndrome in mice. Phytother Res 2003; 17: 938-41.
[15] Hosseinzadeh H, Lary P. Effect of Salvia leriifolia leaf extract on morphine dependence in mice. Phytother Res 2000; 14:1-4.
[16] Rezayat M, Azizi N, Zarrindast MR. On the mechanism(s) of cholecystokinin (CCK): Receptor stimulation attenuates morphine dependence in mice. Pharmacol Toxicol 1997; 81: 124-9.
[17] McIlwain KL, Merriweather MY, Yuva-Paylor LA, Paylor R. The use of behavioral test batteries: Effects of training history. Physiol Behav 2001, 73:705-17.
[18] Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, Laferal FM. Inclusion body myositis-like phenotype induced by transgenic overexpression of β App in skeletal muscle. Pro Natl Acad Sci USA. 2002; 99: 6334-9.
[19] Pardon MC, Perez Diaz F, Joubert C, Cohen Salmon C. Age dependent effects of a chronic ultramild stress procedure on open field behavior in B6D2F1 female mice. Physiology Behavio 2000; 70: 7-13.
[20] Suzuki T, Tsuda M, Narita M, Funada M, Mizoguchi H, Misawa M. Diazepam pretreatment suppresses morphine withdrawal signs in the mouse. Life Sci 1996; 58: 349-57.
[21] Puntillo K, Casella V, Reid M. Opioid and benzodiazepine tolerance and dependence: Application of theory to critical care practice. Heart Lung 1997; 26: 317-24.
[22] Zarrindast MR, Mousa Ahmadi E. Effects of GABAergic system on naloxone-induced jumping in morphine-dependent mice. Eur J Pharmacol 1999; 381: 129-33.
[23] Dunham NM, Miya TS. A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharm Assoc 1957; 46: 208-9.
[24] Hussain, MM, Sokomba EN, Shok M. Pharmacological effects of Gardenia erubescens in mice, rats and cats. Int J Pharmacogn 1991, 29: 94-100.
[25] Hosseinzadeh H, Ramezani M, Namjo N. Muscle relaxant activity of Elaeagnus angostifolia L. fruit seeds in mice. J Ethnopharmacol 2003; 84: 275-8.
[26] Houghton PI, Zarka R, Delas Heras B, Hoult RS. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995; 61: 31-6.
[27] Jion ZH, Chen CC, Lu HY, Chu CP, Ng JJ, Yu S. Effects of Jawey siwu on rat activity. Am J Chin Med 2001; 29: 509-16.
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