Synthesis and Purification of Acamprosate Calcium and its Evaluation by RP-HPLC in Pharmaceutical Dosage Forms Synthesis and Purification of Acamprosate Calcium and its Evaluation by RP-HPLC
Iranian Journal of Pharmaceutical Sciences,
دوره 16 شماره 1 (2020),
15 January 2020
,
صفحه 19-28
https://doi.org/10.22037/ijps.v16.40442
چکیده
The purpose of this study is Acamprosate Calcium synthesis of 3-Aminopropane-1-sulfonic acid (Homotaurine) and validation of assay test in the delayed-release tablets by HPLC without organic solvents. The
assay method by HPLC was found to be linear in the concentration range of 50 to 200 μg/mL. Successful separation was achieved by isocratic elution on a Phenomenex® C18 column (250 mm × 4.6 mm, 5μm).The mobile phase was triethylammonium phosphate buffer pH: 4.0 (100%) at the flow rate of 1 mL/min using UV detection at 210 nm, column oven temperature 25ºC and injection volume 20
- Synthesis
- Evaluation
- Acamprosate Calcium
- RP-HPLC
- Method development
- Pharmaceutical
ارجاع به مقاله
مراجع
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- چکیده مشاهده شده: 120 بار
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