Application of Solvent Extraction for the Removal of Amoxicillin Drug Residues in Environmental Waters Application of Solvent Extraction for the Removal of Amoxicillin Drug Residues in Environmental Waters
Iranian Journal of Pharmaceutical Sciences,
Vol. 15 No. 4 (2019),
1 October 2019
,
Page 41-52
https://doi.org/10.22037/ijps.v15.40453
Abstract
In this study, removal of amoxicillin ions from aqueous medium by liquid-liquid extraction (LLE) technique was investigated. The LLE process coupled by UV-Visible spectroscopy was carried out by response surface
methodology (RSM) based on central composite design (CCD). The process parameters such as extractant concentration, feed acidity, extraction time and diluent type were optimized. At these condition the maximum AMOX extraction was found to be 93.5 % and 96 % using TEA and MDEHPA, respectively. The findings of this study shows that solvent extraction process under the optimum conditions show the considerable potential for environmentally friendly and amoxicillin removal from aqueous media.
Keywords:
- Amoxicillin
- Solvent extraction
- Pharmaceutical pollution
- Wastewater treatment
- Response surface methodology
How to Cite
Seifollahi, Z. ., Abbasi, A. ., & Rahbar-Kelishami, A. . (2019). Application of Solvent Extraction for the Removal of Amoxicillin Drug Residues in Environmental Waters: Application of Solvent Extraction for the Removal of Amoxicillin Drug Residues in Environmental Waters. Iranian Journal of Pharmaceutical Sciences, 15(4), 41–52. https://doi.org/10.22037/ijps.v15.40453
References
[1] Ghauch A, Tuqan A, Assi HA. Antibiotic removal from water: elimination of amoxicillin and ampicillin by microscale and nanoscale iron particles. Environ.pollut. )2009(157(5): 1626-1635.
[2] Chuo SC, Mohd-Setapar SH, Mohamad-Aziz SN, Starov VM. A new method of extraction of amoxicillin using mixed reverse micelles. Colloid .Surf A. )2014( 460: 137-144.
[3] Meltzer EO, Bachert C, Staudinger H. Treating acute rhinosinusitis: comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo. J. Allergy Clin. Immuno. )2005(116(6):1289-1295.
[4] Jones O, Voulvoulis N, Lester J. Human pharmaceuticals in the aquatic environment a review. Environ. technol. )2001( 22 (12): 1383-1394.
[5] Andreozzi R, Canterino M, Marotta R, Paxeus N. Antibiotic removal from wastewaters: the ozonation of amoxicillin. J. hazard. Mater. )2005(122(3): 243-250.
[6] Limousy L, Ghouma I, Ouederni A, Jeguirim M.Amoxicillin removal from aqueous solution using activated carbon prepared by chemical activation of olive stone. Environ. Sci. Pollut. Res. )2017(24(11):
9993-10004.
[7] Derakhshan Z, Mokhtari M, Babaie F, Ahmadi RM, Ehrampoosh MH, Faramarzeian M. Removal Methods of Antibiotic compounds from Aqueous Environments–A Review. J. Environ. Health Sustain Dev )2016(1: 51-74.
[8] Li WC. Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environ. Pollut. )2014(187: 193-201.
[9] Al Aukidy M, Verlicchi P, Jelic A, Petrovic M, Barcelò D. Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy. Sci. Total Environ. )2012( 438: 15-25.
[10] Pirom T, Sunsandee N, Ramakul P, Pancharoen U, Nootong K, Leepipatpiboon N. Separation of amoxicillin using trioctylmethylammonium chloride via a hollow fiber supported liquid membrane:
Modeling and experimental investigation. J. Ind. Eng Chem. )2015( 23: 109-118.
[11] Pirom T, Pancharoen U. Kinetic and Removable of Amoxicillin Using Aliquat336 as a Carrier via a HFSLM. World Academy of Science, Engineering and Technology, Int. J. Chem. Mole. Nucl. Mater. Metall. Eng. (2015) 9 (6): 715-8.
[12] Britto JM, Varela MdCRS. Processos avançados de oxidação de compostos fenólicos em efluentes industriais. (2008).
[13] Morse A, Jackson A. Fate of amoxicillin in two water reclamation systems. Water, Air Soil Poll.)2004( 157 ( 1): 117-132.
[14] Zhang G, Ji S, Xi B. Feasibility study of treatment of amoxillin wastewater with a combination of extraction, Fenton oxidation and reverse osmosis. Desalination )2006(196 (1-3): 32-42.
[15] Ikehata K, Jodeiri Naghashkar N, Gamal El-Din M. Degradation of aqueous pharmaceuticals by ozonation and advanced oxidation processes: a review. Ozone: Sci. Eng. (2006) 28 (6): 353-414.
[16] Shahtalebi A, Sarrafzadeh M, Rahmati MM.Application of nanofiltration membrane in the separation of amoxicillin from pharmaceutical wastewater. Iran. J. Environ. Health Sci. Eng. )2011(8 (2): 109.
[17] Zazouli M, Ulbricht M, Nasseri S, Susanto H. Effect of hydrophilic and hydrophobic organic matter on amoxicillin and cephalexin residuals rejection from water by nanofiltration. Iran. J. Environ. Health Sci.
Eng. )2010( 7 (1): 15.
[18] Elmolla E, Chaudhuri M. Optimization of Fenton process for treatment of amoxicillin, ampicillin and cloxacillin antibiotics in aqueous solution. J. hazard.Mater. )2009( 170 2): 666-672.
[19] Homem V, Alves A, Santos L. Amoxicillin degradation at ppb levels by Fenton's oxidation using design of experiments. Sci. Total. Environ. )2010( 408(24): 6272-6280.
[20] Moradi S. Highly efficient removal of amoxicillin from water by magnetic graphene oxide adsorbent. Chemical Bulletin of ‘Politehnica’University of Timisoara, ROMANIA. Series Chem. Environ. Eng. )2015( 60 (74): 41-48.
[21] Ensano BMB, Borea L, Naddeo V, Belgiorno V, de Luna MDG, Ballesteros FC. Removal of pharmaceuticals from wastewater by intermittent electrocoagulation. Water )2017( 9 (2): 85.
[22] Mansouri H, Carmona RJ, Gomis-Berenguer A, Souissi-Najar S, Ouederni A, Ania CO. Competitive adsorption of ibuprofen and amoxicillin mixtures from aqueous solution on activated carbons. J. Colloid
Interface. Sci. (2015) 449: 252-60.
[23] Pirom T, Pancharoen U. Kinetic and Removable of Amoxicillin Using Aliquat336 as a Carrier via a HFSLM. World Academy of Science, Engineering and Technology, Int. J. Chem. Mole. Nucl. Mater.Metall. Eng. )2015( 9 (6): 715-718.
[24] Pirom T, Sunsandee N, Wongsawa T, Ramakul P, Pancharoen U, Nootong K. The effect of temperature on mass transfer and thermodynamic parameters in the removal of amoxicillin via hollow fiber supported liquid membrane. Chem. Eng. J.)2015( 265: 75-83.
[25] Xu Y, Souza M, Ribeiro-Pontes MZ, Vitolo M,Pessoa-Jr A. Liquid liquid extraction of pharmaceuticals by aqueous two-phase systems. Braz.J. Pharm. Sci. )2001( 37 (3): 305-320.
[26] Gu T. Liquid-liquid partitioning methods for bioseparations. Sep. Sci. Technol. )2000( 2: 329-364.
[27] Homsirikamol C, Sunsandee N, Pancharoen U, Nootong K. Synergistic extraction of amoxicillin from aqueous solution by using binary mixtures of Aliquat 336, D2EHPA and TBP. Sep. Purif. Technol. )2016(
162: 30-36.
[28] Acharya S, Nayak A. Separation of D2EHPA and M2EHPA. Hydrometallurgy )1988(19(3): 309-320.
[29] El-Ashtoukhy E-S, Fouad Y. Liquid–liquid extraction of methylene blue dye from aqueous solutions using sodium dodecylbenzenesulfonate as an extractant. Alexandria. Eng. J. (2015) 54 (1): 77-81.
[30] Seifollahi Z, Rahbar-Kelishami A. Diclofenac extraction from aqueous solution by an emulsion liquid membrane: Parameter study and optimization using the response surface methodology. J. Mole. Liq.
)2017( 231: 1-10.
[2] Chuo SC, Mohd-Setapar SH, Mohamad-Aziz SN, Starov VM. A new method of extraction of amoxicillin using mixed reverse micelles. Colloid .Surf A. )2014( 460: 137-144.
[3] Meltzer EO, Bachert C, Staudinger H. Treating acute rhinosinusitis: comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo. J. Allergy Clin. Immuno. )2005(116(6):1289-1295.
[4] Jones O, Voulvoulis N, Lester J. Human pharmaceuticals in the aquatic environment a review. Environ. technol. )2001( 22 (12): 1383-1394.
[5] Andreozzi R, Canterino M, Marotta R, Paxeus N. Antibiotic removal from wastewaters: the ozonation of amoxicillin. J. hazard. Mater. )2005(122(3): 243-250.
[6] Limousy L, Ghouma I, Ouederni A, Jeguirim M.Amoxicillin removal from aqueous solution using activated carbon prepared by chemical activation of olive stone. Environ. Sci. Pollut. Res. )2017(24(11):
9993-10004.
[7] Derakhshan Z, Mokhtari M, Babaie F, Ahmadi RM, Ehrampoosh MH, Faramarzeian M. Removal Methods of Antibiotic compounds from Aqueous Environments–A Review. J. Environ. Health Sustain Dev )2016(1: 51-74.
[8] Li WC. Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environ. Pollut. )2014(187: 193-201.
[9] Al Aukidy M, Verlicchi P, Jelic A, Petrovic M, Barcelò D. Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy. Sci. Total Environ. )2012( 438: 15-25.
[10] Pirom T, Sunsandee N, Ramakul P, Pancharoen U, Nootong K, Leepipatpiboon N. Separation of amoxicillin using trioctylmethylammonium chloride via a hollow fiber supported liquid membrane:
Modeling and experimental investigation. J. Ind. Eng Chem. )2015( 23: 109-118.
[11] Pirom T, Pancharoen U. Kinetic and Removable of Amoxicillin Using Aliquat336 as a Carrier via a HFSLM. World Academy of Science, Engineering and Technology, Int. J. Chem. Mole. Nucl. Mater. Metall. Eng. (2015) 9 (6): 715-8.
[12] Britto JM, Varela MdCRS. Processos avançados de oxidação de compostos fenólicos em efluentes industriais. (2008).
[13] Morse A, Jackson A. Fate of amoxicillin in two water reclamation systems. Water, Air Soil Poll.)2004( 157 ( 1): 117-132.
[14] Zhang G, Ji S, Xi B. Feasibility study of treatment of amoxillin wastewater with a combination of extraction, Fenton oxidation and reverse osmosis. Desalination )2006(196 (1-3): 32-42.
[15] Ikehata K, Jodeiri Naghashkar N, Gamal El-Din M. Degradation of aqueous pharmaceuticals by ozonation and advanced oxidation processes: a review. Ozone: Sci. Eng. (2006) 28 (6): 353-414.
[16] Shahtalebi A, Sarrafzadeh M, Rahmati MM.Application of nanofiltration membrane in the separation of amoxicillin from pharmaceutical wastewater. Iran. J. Environ. Health Sci. Eng. )2011(8 (2): 109.
[17] Zazouli M, Ulbricht M, Nasseri S, Susanto H. Effect of hydrophilic and hydrophobic organic matter on amoxicillin and cephalexin residuals rejection from water by nanofiltration. Iran. J. Environ. Health Sci.
Eng. )2010( 7 (1): 15.
[18] Elmolla E, Chaudhuri M. Optimization of Fenton process for treatment of amoxicillin, ampicillin and cloxacillin antibiotics in aqueous solution. J. hazard.Mater. )2009( 170 2): 666-672.
[19] Homem V, Alves A, Santos L. Amoxicillin degradation at ppb levels by Fenton's oxidation using design of experiments. Sci. Total. Environ. )2010( 408(24): 6272-6280.
[20] Moradi S. Highly efficient removal of amoxicillin from water by magnetic graphene oxide adsorbent. Chemical Bulletin of ‘Politehnica’University of Timisoara, ROMANIA. Series Chem. Environ. Eng. )2015( 60 (74): 41-48.
[21] Ensano BMB, Borea L, Naddeo V, Belgiorno V, de Luna MDG, Ballesteros FC. Removal of pharmaceuticals from wastewater by intermittent electrocoagulation. Water )2017( 9 (2): 85.
[22] Mansouri H, Carmona RJ, Gomis-Berenguer A, Souissi-Najar S, Ouederni A, Ania CO. Competitive adsorption of ibuprofen and amoxicillin mixtures from aqueous solution on activated carbons. J. Colloid
Interface. Sci. (2015) 449: 252-60.
[23] Pirom T, Pancharoen U. Kinetic and Removable of Amoxicillin Using Aliquat336 as a Carrier via a HFSLM. World Academy of Science, Engineering and Technology, Int. J. Chem. Mole. Nucl. Mater.Metall. Eng. )2015( 9 (6): 715-718.
[24] Pirom T, Sunsandee N, Wongsawa T, Ramakul P, Pancharoen U, Nootong K. The effect of temperature on mass transfer and thermodynamic parameters in the removal of amoxicillin via hollow fiber supported liquid membrane. Chem. Eng. J.)2015( 265: 75-83.
[25] Xu Y, Souza M, Ribeiro-Pontes MZ, Vitolo M,Pessoa-Jr A. Liquid liquid extraction of pharmaceuticals by aqueous two-phase systems. Braz.J. Pharm. Sci. )2001( 37 (3): 305-320.
[26] Gu T. Liquid-liquid partitioning methods for bioseparations. Sep. Sci. Technol. )2000( 2: 329-364.
[27] Homsirikamol C, Sunsandee N, Pancharoen U, Nootong K. Synergistic extraction of amoxicillin from aqueous solution by using binary mixtures of Aliquat 336, D2EHPA and TBP. Sep. Purif. Technol. )2016(
162: 30-36.
[28] Acharya S, Nayak A. Separation of D2EHPA and M2EHPA. Hydrometallurgy )1988(19(3): 309-320.
[29] El-Ashtoukhy E-S, Fouad Y. Liquid–liquid extraction of methylene blue dye from aqueous solutions using sodium dodecylbenzenesulfonate as an extractant. Alexandria. Eng. J. (2015) 54 (1): 77-81.
[30] Seifollahi Z, Rahbar-Kelishami A. Diclofenac extraction from aqueous solution by an emulsion liquid membrane: Parameter study and optimization using the response surface methodology. J. Mole. Liq.
)2017( 231: 1-10.
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