Synthesis and Anti-Tubercular Activity of 6-Substtitutedaryl-4-Arylidene- 4, 5-Dihydropyridazin-3(2H)-One Derivatives against Mycobacterium Tuberculosis Anti-TB activity of some dihydropyridazin-3(2H)-ones
Iranian Journal of Pharmaceutical Sciences,
دوره 15 شماره 3 (2019),
1 تموز 2019
,
صفحه 7-14
https://doi.org/10.22037/ijps.v15.40473
چکیده
Several 4-substituted-benzylidene-6-substituted-phenyl-4,5-dihydro-pyridazin-3(2H)-one derivatives (3a-q) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antitubercular agents. In the first step, 6-aryl-2, 3, 4, 5-tetrahydro-pyridazin-3-ones (2) was prepared by reacting 4-aryl-4-oxobutanoic acids (1) with hydrazine hydrate. Then, aryl-aldehydes were reacted with compounds 2 to furnish pyridazinones (3a-q). Finally, the synthesized compounds were evaluated for their in vitro antitubercular activities against mycobacterium strains and compared to reference drugs streptomycin (MIC value of 6.25μg/mL) and pyrizinamide (MIC value of 3.125μg/mL). Compound 3m and 3n was found to have most significant action. Identity of these compounds was ascertained using IR, NMR and mass spectral data results.
- Pyridazine
- antitubercular
- mycobacterium
- synthesis
- spectral data
ارجاع به مقاله
مراجع
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