The Anti-Angiogenic Activity of Phoenix Dactylifera Seeds Methanol Extract in Vivo Study Phoenix dactylifera seeds Methanol Extract in vivo study
Iranian Journal of Pharmaceutical Sciences,
دوره 14 شماره 2 (2018),
1 فروردین 2018
,
صفحه 83-92
https://doi.org/10.22037/ijps.v14.40665
چکیده
The aim of the study was to identify the antiangiogenic activity of Phoenix dactylifera seeds methanolic extract in vivo and the probable anti-angiogenic mechanism of action. The date seeds were extracted with
methanol using cold method, the crude extract was tested on chick chorioallantoic membrane (CAM) as an in vivo anti-angiogenic assay. Fourier transform infrared spectroscopy FT-IR was carried to identify the functional group for the active chemical constituents. The results demonstrated significant inhibition of blood vessels growth, and FTIR showed the presence of different functional group such as OH, NH2 and phenols. From the data above the mechanism of action may relate to the presence of flavonoids and other phenolic compounds, as they have direct perturbing action on blood vessels and prevent cell proliferation of endothelial cells growth via their potent antioxidant and anti-inflammatory effects.
- CAM assay
- FT-IR
- angiogenesis
- Phoenix dactylifera
- in vivo study
- vascular endothelial growth factor
- antioxidant
- phenolic compounds
- natural compounds
ارجاع به مقاله
مراجع
[2] Rak J, Filmus J and Kerbel R. Reciprocal paracrine interactions between tumor cells and endothelial cells: the angiogenesis progression hypothesis. European Journal of cancer part A (1996), 32(14):2438-2450
[3] Sahib HB., Aisha A.F., Yam Mun Fe., Z. Ismail., Z. Asmawi., S. M. Salhimi., A.M.S. Abdul Majid Anti-angiogenic and anti-oxidant properties of Orthosiphon stamineus Benth. methanolic leaves extract. International journal of pharmacology (2009), 5 (2): 162-167.
[4] Gerhardt H and Betsholtz C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res (2003), 314: 15-23.
[5] Egginton S. Angiogenesis – may the force be with you! J Physiol 2010, 588(23): 4615–4616
[6] Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nature Medicine (1995), 1(1):27-31
[7] Carmeliet P and Jain R K. Angiogenesis in cancer and other diseases. Nature (2000), 407:249-257
[8] Carmeliet P. Angiogenesis in health, disease and medicine. Nature (2005), 438:932-936
[9] Hoeben B Landuyt, Highley MS, Wildiers H, van Oosterom AT, and De ruijn EA. “Vascular endothelial growth factor and angiogenesis,” Pharmacological Reviews (2004), 56(4): 549–580.
[10] Sovak MA, Arsura M, Zanieski G, Kavanagh KT, and Sonenshein GI. “The inhi itory effects of transforming growth factor
- چکیده مشاهده شده: 97 بار
- IJPS_Volume 14_Issue 2_Pages 83-92 (English) دانلود شده: 26 بار