The Effect of Elaeagnus angustifolia L. Cream on Radiation-Induced Skin Reactions in Women with Breast Cancer; A Preliminary Clinical Trial Running title?????
Iranian Journal of Pharmaceutical Sciences,
Vol. 13 No. 2 (2017),
1 April 2017
,
Page 25-36
https://doi.org/10.22037/ijps.v13.40687
Abstract
Radiotherapy, a highly effective way to destroy breast cancer, causes skin adverse effects. A considerable amount of studies have been conducted to find a way to alleviate or relieve dermal adverse effects of radiation. The aim of this study was to observe the clinical effect of Elaeagnus angustifolia L. cream to treat radiotherapy-induced skin destruction in breast cancer patients.Thirty two patients suffering from different stages of radiotherapy-induced skin reactions were evaluated in a double-blind randomized study; 16 patients in the treatment group received Elaeagnus angustifolia cream, while the other 16 patients, served as control group.Two weeks after the treatment, patients in Elaeagnus angustifolia group showed significantly lower skin reaction grade compared with placebo group. The attitude of the patients of Elaeagnus angustifolia group about dryness, itching, pain, burning, blisters and sores was significantly improved after two weeks of treatment.Elaeagnus angustifolia cream may effectively reduce the radiotherapy-induced dermal injury.
Keywords:
- Elaeagnus angustifolia
- Breast cancer
- Radiotherapy
- Skin reaction
- Russian olive
- Radiation
How to Cite
Jamshid Salamzadeh, Mohammad Kamalinejad, Mohammad Babaeian, Bahram Mofid, Seyed Alireza Mortazavi, & Alireza Sheikhlar. (2017). The Effect of Elaeagnus angustifolia L. Cream on Radiation-Induced Skin Reactions in Women with Breast Cancer; A Preliminary Clinical Trial: Running title?????. Iranian Journal of Pharmaceutical Sciences, 13(2), 25–36. https://doi.org/10.22037/ijps.v13.40687
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[41] I. Merfort, J. Heilmann, U. Hagedorn-Leweke, B.C. Lippold, In vivo skin penetration studies of camomile flavones, Pharmazie 49(7) (1994) 509-11.
[42] N. Moezzi, H. Najafzadeh Varzi, S. Shirali, Comparing the effect of Elaeagnus angustifolia L. extract and Lowsonia intermis L. paste, with silver sulfadiazine ointment on wound healing in rat, Iranian Journal of Medicinal and Aromatic Plants 25(2) (2009) 253-260.
[2] P. Yavari, M. Mosavizadeh, B. Sadrol-Hefazi, Y. Mehrabi, Reproductive characteristics and the risk of breast cancer - A case-control study in Iran, Asian Pacific Journal of Cancer Prevention 6(3) (2005) 370-375.
[3] J. Fisher, C. Scott, R. Stevens, B. Marconi, L. Champion, G.M. Freedman, F. Asrari, M. Pilepich, J.D. Gagnon, G. Wong, Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13, International Journal of Radiation Oncology* Biology* Physics 48(5) (2000) 1307-1310.
[4] S. Heggie, G.P. Bryant, L. Tripcony, J. Keller, P. Rose, M. Glendenning, J. Heath, A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue, Cancer Nurs 25(6) (2002) 442-451.
[5] F. Pommier P Fau - Gomez, M.P. Gomez F Fau - Sunyach, A. Sunyach Mp Fau - D'Hombres, C. D'Hombres A Fau - Carrie, X. Carrie C Fau - Montbarbon, M. X, Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer, J Clin Oncol 22(8) (2004) 1447-53.
[6] E. Szumacher, A. Wighton, E. Franssen, E. Chow, M. Tsao, I. Ackerman, L. Andersson, J. Kim, A. Wojcicka, Y. Ung, K. Sixel, C. Hayter, Phase II study assessing the effectiveness of Biafine cream as a prophylactic agent for radiation-induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy, International Journal of Radiation Oncology*Biology*Physics 51(1) (2001) 81-86.
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[8] K. Hassey, C. Rose, Altered skin integrity in patients receiving radiation therapy, Oncology nursing forum, 1982, p. 44.
[9] S.G. Margolin, J.C. Breneman, D.L. Denman, P. LaChapelle, L. Weckbach, B.S. Aron, Management of radiation-induced moist skin desquamation using hydrocolloid dressing, Cancer Nurs 13(2) (1990) 71-80.
[10] D.J. Dudek, J. Thompson, M.M. Meegan, T.R. Haycocks, C. Barbieri, L.A. Manchul, Pilot study to investigate the toxicity of Aloe vera gel in the management of radiation induced skin reactions for post-operative primary breast cancer, Journal of Radiotherapy in Practice 1(04) (1999) 197-204.
[11] D.L. Olsen, W. Raub Jr, C. Bradley, M. Johnson, J.L. Macias, V. Love, A. Markoe, The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy, Oncology nursing forum, 2001, p. 543.
[12] V. Liguori, C. Guillemin, G.F. Pesce, R.O. Mirimanoff, J. Bernier, Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy, Radiotherapy and Oncology 42(2) (1997) 155-161.
[13] M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, A. Munro, Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial, Radiotherapy and Oncology 73(2) (2004) 153-162.
[14] J.J. Yohn, W.L. Weston, Topical corticosteroids, in Weston WL (ed): Current Problems in Dermatology, Year Book Medical, Chicago, 1990.
[15] A. Bostrom, H. Lindman, C. Swartling, B. Berne, J. Bergh, Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study, Radiother Oncol 59(3) (2001) 257-265.
[16] M. Schmuth, M.A. Wimmer, S. Hofer, A. Sztankay, G. Weinlich, D.M. Linder, P.M. Elias, P.O. Fritsch, E. Fritsch, Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study, Br J Dermatol. 146(6) (2002) 983-91.
[17] A. Korinko, A. Yurick, Maintaining skin integrity during radiation therapy, Am J Nurs 97(2) (1997) 40-44.
[18] C.T. Spann, W.D. Tutrone, J.M. Weinberg, N. Scheinfeld, B. Ross, Topical antibacterial agents for wound care: a primer, Dermatol Surg 29(6) (2003) 620-6.
[19] M. Moolenaar, R. Louwrens Poorter, P. Paulus Gerardus Van Der Toorn, A. Willem Lenderink, P. Poortmans, A. Cornelis Gerardus Egberts, The effect of honey compared to conventional treatment on healing of radiotherapy-induced skin toxicity in breast cancer patients, Acta Oncologica 45(5) (2006) 623-624.
[20] J.F. Fowler, The radiobiology of prostate cancer including new aspects of fractionated radiotherapy, Acta Oncologica 44(3) (2005) 265-276.
[21] H. Mirhydar, Encyclopedia of Plants: Indications of Plants in the Prevention and Treatment of Diseases, Islamic Farhang, Tehran, 1998.
[22] A. Ahmadiani, J. Hosseiny, S. Semnanian, M. Javan, F. Saeedi, M. Kamalinejad, S. Saremi, Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract, Journal of Ethnopharmacology 72(1–2) (2000) 287-292.
[23] H. Hosseinzadeh, M. Ramezani, N. Namjo, Muscle relaxant activity of Elaeagnus angustifolia L. fruit seeds in mice, Journal of Ethnopharmacology 84(2–3) (2003) 275-278.
[24] M. Momen Hosseini, Tohfeh Hakim Momen, Mahmoudi Publication, Tehran, 1981.
[25] Avicenna, The Canon of Medicine, 5 ed., Soroush Publication, Tehran, 1991.
[26] A. Ansari Shirazi, Ekhtiyarat Badii, Razi Publication, Tehran 1991.
[27] A. Zargari, Medicinal Plants, Tehran University Press, Tehran, 1990.
[28] G.H. Alishiri, A. Ahmadiani, N. Bayat, M. Kamalinejad, A. Salimzadeh, S. Saremi, M. Miri, A.A. Noudeh, Efficacy of Elaeagnus Angustifolia Extract in Treatment of Osteoarthritis of Knee: A Randomized Double-Blind Placebo-Controlled Trial, Kowsar Medical Journal 12(1) (2007) 49-57.
[29] L. Perry, Medicinal Plants of the East and Southeast Asia, MIT Press, London, 1980.
[30] İ. Gürbüz, O. Üstün, E. Yesilada, E. Sezik, O. Kutsal, Anti-ulcerogenic activity of some plants used as folk remedy in Turkey, J Ethnopharmacol 88(1) (2003) 93-97.
[31] Q. Wang, X. Ruan, J.-H. Huang, N.-y. Xu, Q.-c. Yan, Intra-specific genetic relationship analyses of Elaeagnus angustifolia based on RP-HPLC biochemical markers, Journal of Zhejiang University Science B 7(4) (2006) 272-278.
[32] M. Karamedini, A. Rohani, Isolation and investigation of antimicrobial activity of total flavonoids of Elaeagnus angustifolia, JOURNAL OF PHARMACY AND PHARMACOLOGY 55 (2003) 152-152.
[33] M. Mehrabani Natanzi, P. Pasalar, M. Kamalinejad, A.R. Dehpour, S.M. Tavangar, R. Sharifi, N. Ghanadian, M. Rahimi-Balaei, S. Gerayesh-Nejad, Effect of aqueous extract of Elaeagnus angustifolia fruit on experimental cutaneous wound healing in rats, Acta medica Iranica 50(9) (2012) 589-596.
[34] L. Bucur, G. Taralunga, R. Alexandrescu, T. Negreanu, V. Istudor, [Evaluation of biological activity of a dermatological preparation with elaeagnus angustifolia flowers soft extract], Rev Med Chir Soc Med Nat Iasi 112(4) (2008) 1098-103.
[35] L.H. Sobin, C.C. Compton, TNM seventh edition: What's new, what's changed, Cancer 116(22) (2010) 5336-5339.
[36] S. Farahbakhsh, S. Arbabian, F. Emami, B. Rastegar Moghadam, H. Ghoshooni, A. Noroozzadeh, H. Sahraei, L. Golmanesh, C. Jalili, H. Zrdooz, Inhibition of Cyclooxygenase Type 1 and 2 Enzyme by Aqueous Extract of Elaeagnus Angustifolia in Mice, Basic and Clinical Neuroscience 2(2) (2011) 31-37.
[37] M. del Carmen Recio, R.M. Giner, S. Manez, A. Talens, L. Cubells, J. Gueho, H.R. Julien, K.Hostettmann, J.L. Rios, Anti-inflammatory activity of flavonol glycosides from Erythrospermum monticolum depending on single or repeated local TPA administration, Planta Med 61(6) (1995) 502-4.
[38] A. Panthong, W. Tassaneeyakul, D. Kanjanapothi, P. Tantiwachwuttikul, V. Reutrakul, Anti-inflammatory activity of 5,7-dimethoxyflavone, Planta Medica 55(2) (1989) 133-136.
[39] M.J. Alcaraz, J.R. Hoult, Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside, on prostaglandin biosynthesis and inactivation, Biochem Pharmacol 34(14) (1985) 2477-2482.
[40] M. Alcaraz, M. Moroney, J. Hoult, Effects of Hypolaetin-8-O-glucoside and its Aglycone in in vivo and in vitro Tests for Anti-Inflammatory agents, Planta Medica 55(01) (1989) 107-108.
[41] I. Merfort, J. Heilmann, U. Hagedorn-Leweke, B.C. Lippold, In vivo skin penetration studies of camomile flavones, Pharmazie 49(7) (1994) 509-11.
[42] N. Moezzi, H. Najafzadeh Varzi, S. Shirali, Comparing the effect of Elaeagnus angustifolia L. extract and Lowsonia intermis L. paste, with silver sulfadiazine ointment on wound healing in rat, Iranian Journal of Medicinal and Aromatic Plants 25(2) (2009) 253-260.
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