The Role of Olea Europaea L. Fruit on A2780, A172 and HFFF2 Proliferation Olive activates c ell proliferation
Iranian Journal of Pharmaceutical Sciences,
Vol. 12 No. 4 (2016),
1 Mehr 2016
,
Page 55-62
https://doi.org/10.22037/ijps.v12.40713
Abstract
Olea europaea L. commonly known as olive has been traditionally used for the prevention and treatment of many diseases since ancient times. Olive has been reported to possess a broad spectrum of pharmacological properties. In the present study, we investigated the activity of aqueous extract of Olea europaea L. fruit at various concentrations on A2780, A172, and HFFF2 cell lines proliferation by MTT assay. Aqueous extract of olive significantly increased cell proliferation in a dose dependent manner in the cell lines. It has been previously reported that olive has chemoproventive and anti-tumor effects. These disagreements can be explained by differences in cell line properties, type of olive and different solvents in the extracts. However, further investigation is needed to clarify the exact role of olive in cell proliferation and cancer. In this study fruit extract of Olea europaea L. showed more activatory effects on A2780 cell line in comparison with A172 and HFFF2. These differences in the activatory effects may be related to the activation of different signaling pathways in different cell lines.
- Activatory effects
- A2780
- A172
- Cell Proliferation
- HFFF2
- Olea europaea L
- Olive
How to Cite
References
[2] Keys A, Menotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R, Djordjevic BS, Dontas AS, Fidanza F, Keys MH, et al. The diet and 15-year death rate in the Seven Countries Study. Am J Epidemiol. 1986; 124:903-15.
[3] Owen RW, Haubner R, Würtele G, Hull E, Spiegelhalder B, Bartsch H. Olivesand olive oil in cancer prevention. Eur J Cancer Prev.2004; 13:319-26.
[4] Harwood JL, Yaqoob P. Nutritional and healthaspects of olive oil. Eur J Lipid Sci Technol. 2002; 104:685-97.
[5] Hashmi MA, Khan A, Hanif M, Farooq U, Perveen S. Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive). Evid Based Complement Alternat Med. 2015; 2015: 541591
[6] Ryan D, Robards K. Phenolic compounds in olives. Analyst. 1998, 123:31R–44R.
[7] Covas MI, Nyyssönen K, Poulsen HE, Kaikkonen J, Zunft HJ, Kiesewetter H, Gaddi A, de la Torre R, Mursu J, Bäumler H, Nascetti S, Salonen JT, Fitó M, Virtanen J, Marrugat J; EUROLIVE Study Group. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006; 145(5):333-41.
[8] Owen RW, Giacosa A, Hull WE, Haubner R, Würtele G, Spiegelhalder B, Bartsch H. Olive oil consumption and health: the possible role of antioxidants. Lancet Oncol. 2000; 1:107-112.
[9] Sahranavard S, Kamalinejad M, Faizi M. Evaluation of Anti-Inflammatory and Anti-Nociceptive Effects of Defatted Fruit Extract of Olea europaea. Iran J Pharm Res. 2014; 13(Suppl):119-23.
[10] Hamdi HK, Castellon R. Oleuropein, a nontoxicolive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Biophys Res Commun.2005; 334:769-78.
[11] Domitrović R, Jakovac H, Marchesi VV, Šain I, Romić Ž, Rahelić D. Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice. Pharmacol Res. 2012; 65(4): 451-64.
[12] de Lorgeril M, Salen P. The Mediterranean diet insecondary prevention of coronary heart disease. Clin Invest Med. 2006; 29:154-8.
[13] Aviram, M. Interaction of oxidized low density lipoprotein with macrophages in atherosclerosis,and the antiatherogenicity of antioxidants. Eur J Clin Chem Clin Biochem. 1996, 34:599–608.
[14] Fabiani R, De Bartolomeo A, Rosignoli P, Servili M, Montedoro GF, Morozzi G. Cancer chemoprevention by hydroxytyrosol isolatedfrom virgin olive oil through G1 cell cycle arrest and apoptosis. Eur J Cancer Prev. 2002; 11:351-8.
[15] Romero C, Medina E, Vargas J, Brenes M, De Castro A. In vitro activityof olive oil polyphenols against Helicobacter pylori. J Agric Food Chem. 2007; 55:680-6.
[16] Carollo C, Presti RL, Caimi G. Wine, diet, andarterial hypertension. Angiology. 2007; 58:92-6.
[17] Fitó M, Covas MI, Lamuela-Raventós RM, Vila J, Torrents L, de la Torre C, Marrugat J. Protective effect of olive oil and its phenolic compounds against low density lipoprotein oxidation. Lipids. 2000; 35:633–8.
[18] Mirmohammadlu M, Hosseini SH, Esmaeili Gavgani M, Kamalinejad M, Noubarani M, Eskandari MR. Hypolipidemic, hepatoprotective and renoprotective effects of Cydonia oblonga Mill. fruit in streptozotocin-induced diabetic rats. Iran J Pharm Res. 2015;14(4): 1207-14.
[19] Heidari H, Kamalinejad M, Noubarani M, Rahmati M, Jafarian I, Adiban H, Eskandari MR. Protective mechanisms of Cucumis sativus in diabetes-related modelsof oxidative stress and carbonyl stress. Bioimpacts. 2016; 6(1):33-9.
[20] Jamali B, Nakhjavani M, Hosseinzadeh L, Amidi S, Nikounezhad N, H Shirazi F. Intracellular GSH Alterations and Its Relationship to Level of Resistance following Exposure to Cisplatin in Cancer Cells. Iran J Pharm Res. 2015; 14(2):513-9.
[21] Ramazani A, Mashhadi M, Kamalinejad M, Tavakolizadeh M, Balaghi F, Noubarani M, Eskandari MR, Shirazi F.H. Phoenix dactylifera L. Fruit induces cell proliferation of A2780, A172 and HFFF2 cell lines. Iran J Pharm Res. 2016; 12(1): 35-44.
[22] Fares R, Bazzi S, Baydoun SE, Abdel-Massih RM. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract. Plant Foods Hum Nutr. 2011; 66(1):58-63.
[23] Turkez H, Togar B, Polat E. Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats. Cytotechnology. 2012; 64(4):459–64.
[24] Waterman E, Lockwood B. Active components and clinical applications of olive oil.Altern Med Rev. 2007; 12(4):331-42.
[25] Tuck KL, Hayball PJ. Major phenolic compoundsin olive oil: metabolism and health effects. J Nutr Biochem. 2002; 13:636-44.
[26] Visioli F, Poli A, Gall C. Antioxidant and otherbiological activities of phenols from olives and oliveoil. Med Res Rev. 2002; 22:65-75.
[27] Vilaplana-Pérez C, Auñón D, García-Flores LA, Gil-Izquierdo A. Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS. Front Nutr. 2014; 1: 18.
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