Survey of Availability, Use and Knowledge about Toxicity of Diphenhydramine for Children among Iranian Mothers Mothers Knowledge about Toxicity of Diphenhydramine for Infants
Iranian Journal of Pharmaceutical Sciences,
Vol. 9 No. 3 (2013),
1 July 2013
,
Page 11-16
https://doi.org/10.22037/ijps.v9.40869
Abstract
Diphenhydramine, as an antihistamine drug is widely used for the treatment of allergies. However, being classified as an over the counter medication and the general belief on the low adverse effect profile of this drug has made it widely accessible to the families. Recent reports of diphenhydramine intoxication and mortality, noticeably in children and infants have raised some serious concerns. In the present study, 241 mothers who referred to four different regional locations of mother and child health care service centers were asked to fill up a questionnaire on diphenhydramine. The results of our study showed that besides the lack of adequate information on the indications and safety of the drug, 97% of the mothers used this medication for different illness conditions of the children, with more than 20% misindications on respiratory infections, fever and pain conditions. More than 40% of mothers did not have specific idea about the age related restrictions of the medication and 81% had no information on the proper dose indication. Furthermore 86% of mothers had no information about its adverse effects and the rest of them knew only about drug induced drowsiness. The results of this study show that diphenhydramine usage should be more closely observed, the pharmacists should make consult families before providing them with diphenhydramine, the pharmaceutical companies should be obliged to provide a drug information sheet in the packaging, and the public media and various health care providers should also feel responsibility to forewarn mothers about the results of self-prescribed medication.
- Acknowledgments
- Diphenhydramine
- Infants
- Mothers
- Toxicity
How to Cite
References
[2] Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Dart RC. 2012 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 30th Annual Report. Clinical toxicology(2013,51(10):949-1229.
[3] Goetz CM, Lopez G, Dean BS, Krenzelok EP. Accidental childhood death from diphenhydramine overdosage. The American journal of emergency medicine(1990),8(4):321-322.
[4] Hausmann E, Wewer H, Wellhoner HH, Weller J-P. Lethal intoxication with diphenhydramine. Archives of Toxicology(1983),53(1):33-39.
[5] Huston RL, Cypcar D, Cheng GS, Foulds DM. Toxicity from topical administration of diphenhydramine in children. Clinical pediatrics(1990),29(9):542-545.
[6] Pragst F, Herre S, Bakdash A. Poisonings with diphenhydramine, a survey of 68 clinical and 55 death cases. Forensic science international(2006),161(2):189-197.
[7] Hestand HE, Teske DW. Diphenhydramine hydrochloride intoxication. The Journal of pediatrics.(1977),90(6):1017-1018.
[8] Scharman EJ, Erdman AR, Wax PM, Chyka PA, Martin Caravati E, Nelson LS, et al. Diphenhydramine and Dimenhydrinate Poisoning: an Evidence-Based Consensus Guideline for Out-of-Hospital Management. Clinical toxicology(2006),44(3):205-523.
[9] Sype JW, Khan IA. Prolonged QT interval with markedly abnormal ventricular repolarization in diphenhydramine overdose. International journal of cardiology(2005),99(2):333-335.
[10] Lindsay CA, Williams GD, Levin DL. Fatal adult respiratory distress syndrome after diphenhydramine toxicity in a child: a case report. Critical care medicine(1995),23(4):777-781.
[11] Baena-Cagnani CE. Safety and tolerability of treatments for allergic rhinitis in children. Drug safety (2004),27(12):883-898.
[12] Simons F, Fraser TG, Reggin JD, Roberts JR, Simons KJ. Adverse central nervous system effects of older antihistamines in children. Pediatric allergy and immunology(1996),7(1):22-27.
[13] Simons FE. H1-antihistamines in children. Clinical allergy and immunology(2002),17:437-464.
[14] Ten Eick AP, Blumer JL, Reed MD. Safety of antihistamines in children. Drug safety(2001),24(2):119-147.
[15] Tabnak professional news site: http://www.tabnak.ir/fa/news/341384.
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