Formulation Design and Evaluation of Hydrogel-Based Metronidazole Bioadhesive Tablet for Vaginal Candidiasis Hydrogel based tablet for vaginal candidiasis
Iranian Journal of Pharmaceutical Sciences,
مجلد 9 عدد 1 (2013),
6 February 2024
,
الصفحة 25-37
https://doi.org/10.22037/ijps.v9.40915
الملخص
Hydrogel-Based Metronidazole Bioadhesive Tablet (HMBT) was prepared as a novel vaginal delivery system to achieve Controlled release of drug from the tablet for vaginal candidiasis. The highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by SEM, DSC and FT-IR and evaluated for % swelling. The drug loaded hydrogels were incorporated into tablet formulation by dry granulation method using bioadhesive polymers such as HPMC, sodium CMC and guar gum in different ratios. HMBT was tested for drug content, hardness, friability, weight variation, thickness, swelling studies, in vitro drug release, bioadhesive strength, in vivo studies and antifungal activity. The FT-IR and DSC spectra’s revealed that there was no chemical interaction between drug and polymers used. SEM revealed that particles of hydrogels appeared small and irregular shaped with large numbers of pores. F3 formulation shows good in vitro release profile with highest bioadhesive strength. From the in vivo study in rabbit it was found that the HMBT hold the tablet for more than 12 hours inside the vaginal tube. It may be concluded from present study that HMBT can be used as a novel delivery system for local therapy of vaginal candidiasis which can controlled the release of drug for prolong period of time.
- Antifungal activity
- Bioadhesive Tablet
- candidiasis
- Hydrogel,
- Metronidazole
- vaginal.
كيفية الاقتباس
المراجع
[2] Benkop-Schnurch A, Hornof M. Intravaginal drug delivery systems: design, challenges and solutions. Am J Drug Deliv, 2003, 1(4): 241–54.
[3] Iyer V, Bendgude N, Poddar SS. Vaginal drug delivery. Express Pharma, 2008.( Accessed 19 March 2009).
[4] Cohen MS, Black JR, Proctor RA, Sparling PF. Host defenses and the vaginal mucosa: a re-evaluation. Scand J Urol Nephrol, 1984, 86: 3–22.
[5] Hani U, Bhat RS, Ritesh S, Shivakumar HG. Novel vaginal drug delivery systems: a review. Curr Drug Ther, 2010, 5: 95-104.
[6] Hani U, Bhat RS, Shivakumar HG. Formulation design and evaluation of metronidazole microspheres in a bioadhesive gel for local therapy of vaginal candidiasis. Lat Am J Pharm, 2011, 30(1): 161-7.
[7] Bouckaert S, Temmerman M, Voorspoels J, VanKets H, Remon JP, Dhont M. Preliminary efficacy study of a bioadhesive vaginal metronidazole tab let in the treatment of bacterial vaginosis. J Pharm Pharmacol, 1995, 47: 970–971.
[8]Kukner S, Ergin T, Cicek N, Ugur M, Yesilyurt H, Gokmen O. Treatment of vaginitis. Int J Gynecol Obstet,1996, 52: 43–47.
[9] Mandal TK. Swelling-controlled release system for the vaginal delivery of miconazole. Eur J Pharma Biopharma, 2000, 50: 337-43.
[10] Karasulu HY, Hilmioglu S, Metin DY, Guneri T. Efficacy of a new ketoconazole bioadhesive vaginal tablet on candida albicans, IL Farmaco, 2004, 59: 163-7.
[11] Satish C, Satish K, Shivakumar H. Hydrogels as controlled delivery system: synthesis, crosslinking, water and drug transport mechanism. Indian J Pharm Sci, 2006, 68(2): 133-40.
[12] Narayan B, Jonathan G, Miqin Z. Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Del Reviews, 2010, 62: 83–99.
[13] Alam MA, Ahmad FJ, Khan ZI, Khar RK, Ali M. Development and evaluation of acid-buffering bioadhesive vaginal tablet for mixed vaginal infections. AAPS Pharm Sci Tech, 2007, 8(4): E1-8.
[14] Gupta NV, Satish CS, Shivakumar HG. Preparation and characterization of gelatin-poly (meth acrylic acid) interpenetrating polymeric network hydrogels as a pH-sensitive delivery system for Glipizide. Ind J Pharm Sci, 2007, 64-8.
[15] Tamura H, Wada K, Rujiravanit R, Tokura S.Preservation of chitosan aqueous gel under neutral conditions. J. Metals, Materials and Mineral, 2005, 15(1): 19-21.
[16] Shaheen SM, Yamura K. Preparation of theoph ylline hydrogels of atatic poly (vinyl alcohol)/ NaCl/ H2O system for drug delivery system. J Control Release, 2002, 81: 367-77.
[17] Rao YM, Vani G, Chary BR. Design and evaluation of mucoadhesive drug delivery systems. Indian Drugs, 1998, 35(9): 558-65.
[18] Kast CE, Valenta C, Leopold M, Schnurch AB. Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole. J Control Release, 2002, 81: 347-54.
[19] Park K, Park H. Test methods of bioadhesion, In: Bioadhesive Drug Delivery Systems; Florida: CRC Press, Boca Raton, 1990: 43.
[20] Lin CC, Metters AT. Hydrogels in controlled release formulations: Network design and mathematical modeling. Advanced Drug Delivery Reviews, 2006, 58: 379-408.
- الملخص المشاهدات: 103 الأوقات
- IJPS_Volume 9_Issue 1_Pages 25-37 (English) التنزيلات: 26 الأوقات