A Modified Solvent Method for Preparation of Solid Dispersions Preparation of solid dispersions
Iranian Journal of Pharmaceutical Sciences,
دوره 8 شماره 1 (2012),
15 January 2012
,
صفحه 287-298
https://doi.org/10.22037/ijps.v8.40979
چکیده
The first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using PEG 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. The second objective was to apply the modified solvent method for preparation of sustained release
solid dispersions of domperidone with Eudragit RLPO as a carrier. The solid dispersions of oxcarbazepine and quetiapine were prepared using spray drying and a modified solvent evaporation method. The modified method was then used to prepare solid dispersion of domperidone. All the preparations were evaluated for solubility and dissolution. The characterization was done using FTIR, PXRD and
DSC. The solubility and dissolution rates increased significantly for oxcarbazepine and quetiapine in the solid dispersion with PEG 6000. The release of domperidone was decreased in the solid dispersion with Eudragit RLPO. The solubility and dissolution rates of oxcarbazepine and quetiapine were increased significanly in the solid dispersions prepared by both spray drying and modified solvent method.
There was no significant difference in the release profiles of solid dispersion prepared by the two methods. The modified solvent method was effectively used for preparing sustained release solid dispersion of domperidone.
- Domperidone
- Oxcarbazepine
- Quetiapine
- Solid dispersions
- Solvent
- Spray drying.
ارجاع به مقاله
مراجع
[2] Chiou WL, Riegelman S. Preparation and dissolution characterization of several fast release solid dispersions of Griseofulvin. J Pharm Sci 1969; 58: 1505-10.
[3] Newa M, Bhandari KH, Xun Li D, Kwon T.Preparation, characterization and in vivo evaluation of ibuprofen binary solid dispersions with poloxamer 188. Int J Pharm 2007; 343:228-37.
[4] Nagarsenker MS, Garad SD, Ramprakash G.Design, optimization and evaluation of domperidone coevaporates. J Controlled Release 2000; 63: 31-9.
[5] Geppi M, Guccione S, Mollica G, Pignatello R, Veracini CA. Molecular properties of ibuprofen and its solid dispersions with Eudragit RL100 studied by solid-state nuclear magnetic resonance.Pharm Res 2005; 22: DOI: 10.1007/s11095-005-6249-5.
[6] Mahaparale PR, Gudsoorkar VR, Kuchekar GB.Studies on solid dispersions of meloxicam. Indian J Pharm Edu Res 2006; 40: 241-4.
[7] Londhe YY, Nagarsenkar MS. Solid dispersions of hydroxypropyl b-cyclodextrin and carbamazepine: study on complexation and in vitro dissolution profile. Indian Drugs 1999; 36:15-20.
[8] Ahuja N, Katare OP, Singh B. Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur J Pharm Biopharm 2007; 65: 26-38.
[9] Rescigno A. Bioequivalence. Pharm Res 1992; 9:925-8.
[10] Moore JW, Flanner HH. Mathematical comparison of dissolution profiles. Pharm Tech 1996; 20: 64-74.
[11] Goskonda VR, Reddy IK, Durrani MJ, Wilber W, Khan MA. Solid-state stability assessment of controlled release tablets containing Carbopol 971 P. J Controlled Release 1998; 54: 87-93.
[12] Anderson NH, Bauer M, Boussac N, Khan-Malek R, Munden P, Sardaro M. An evaluation of fit factors and dissolution efficiency for the comparison of in vitro dissolution profiles. J Pharm Biomed Anal 1998; 17: 811-22.
[13] The European Agency for the Evaluation of Medicinal Products (EMEA). Human medicines evaluation unit, note for guidance on quality of modified released products: A. oral dosage forms,B. transdermal dosage forms; Section 1 (Quality) 1999; CPMP/QWP/604/96.
[14] Shah VP, Tsong Y, Sathe P, Liu J. In vitro dissolution profile comparison-statistics and analysis of the similarity factor f2. Pharm Res 1998; 15: 889-95.
[15] Verheyen S, Blaton N, Kinget R, Van den Mooter G. Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions. Int J Pharm 2002; 249: 45-58.
[16] Dahiya S, Pathak K, Sharma R. Development of extended release coevaporates and coprecipitates of promethazine HCl with acrylic polymers: formulation considerations. Chem Pharm Bull 2008; 56: 504-8.
[17] Dabbagh MA, Taghipour B. Investigation of solid dispersion technique in improvement of physicochemical characteristics of ibuprofen powder.Iranian J Pharm Sci 2007; 3: 69-76.
[18] Mishra DN, Vijayakumar SG. Preparation characterization and in vitro studies of solid dispersions of meloxicam with PEG 6000. Yakugaku Zasshi 2006; 126: 657-64.
[19] Betageri GV, Makarla KR. Enhancement of dissolution of glyburide by solid dispersion and lyophilization techniques. Int J Pharm 1995; 126:155-60.
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