Wound Healing and Toxicity Evaluation of Aloe vera Cream on Outpatients with Second Degree Burns Effect of Aloe Veracream on wound burns
Iranian Journal of Pharmaceutical Sciences,
Vol. 3 No. 3 (2007),
1 July 2007
,
Page 157-160
https://doi.org/10.22037/ijps.v3.41013
Abstract
Aloe verais a tropical plant belonging to the Liliaceae family. It has beneficialeffects in variety of diseases. The aim of this study was to formulate a topical creamfrom A. verawith wound burn healing effect and to perform its clinical trial. Atotalof 30 patients (20 males and 10 females in the age range of 20-50 years) with seconddegree burn wounds on their both hands were selected for the study. The subjectsused A. veratopical formulation or silver sulfadiazine 1% cream on each hand asthe test and control, symmetrically. The rate of healing was measured and comparedon 0 to 18 days after treatment. Results indicated that average percent of healingwith A. veraon day 10 was 90.6% compared with silver sulfadiazine which was only29.8% (p<0.001). Toxicity monitoring of the burn surfaces during healing courseaccording to patient responses showed neither rashes, swelling, inflammation,redness, irritation, itching nor any other toxicity symptoms. Significant effect ofA. veraon burn wounds without any adverse dermal toxic effects is very promisingand it may be employed in management of burn wound, routinely.
- Aloe vera
- Burn
- Cream
- Silver sulfadiazine
- Wound healing
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References
[2]Newall CA, Anderson LA, Phillipson JD. Theherbal medicines. London: The PharmaceuticalPress, 1996; pp. 25-7.
[3]Wendell LC. Aloe vera. Bloomfield: JobsonPublication, 2005; p. 1.
[4]Klein A, Penneys N. Aloe vera. J Am AcadDermatol1988; 18: 714-20.
[5] Sabeh F, Wright T, Norton SJ. Purification andcharacterization of glutathione peroxidase fromAloe veraplant. Enzyme Protein 1993; 47: 92-8.
[6]Sabeh F, Wright T, Norton SJ. Isozymes ofsuperoxide dismutase from Aloe vera. Enzymeprotein 1996; 49: 212-21.
[7]Moghbel A, Agheli H,. Hemati A, Rasidi I. Burncongress abstract book. Tehran, 2002; p. 124,130.
[8]Moghbel A, Hemati A, Agheli H, Rashidi I,Amraee K. The effect of tragacanth mucilage onthe healing of full-thickness wound in rabbit.Arch Iranian Med2005; 8: 257-62.
[9]Troyer M. Principle and techniques ofhistochemistry.Masachoset: Little BrownCompany, 1980.
[10]Zawahary ME, Hejazy MR, Helal M. Use ofAloe verain treating leg ulcers and dermatoses.Int J Dermatol1973; 12: 68-73.
[11]You IC, Hi Y, Ag AW. Alot of unfavorable outcome of burn patients with neuropsy chiatricdisorders. Tohoka J Med2005; 205: 241-5.
[12]Davis RH, Donato JJ, Harthman GM, Haas RC.Antiinflammatory and wound healing activity ofgrowth substance in Aloe vera. J Am PodiatrMed Assoc1994; 84: 77-81.
[13]Thomas DR, Goode PS, LaMaster K, TennysonT. Acemannan hydrogel dressing versus salinedressing for pressure ulcers. Arandomized,controlled trial. Adv Wound Care1998; 11: 273-6.
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