Exploring the Protective Effect of Ascorbic Acid and AqueousExtract of Spirulina platensison Methotrexate-Induced Lipid Peroxidation Antioxidant effect of Spirulina platensis
Iranian Journal of Pharmaceutical Sciences,
Vol. 3 Núm. 4 (2007),
1 October 2007
,
Página 217-228
https://doi.org/10.22037/ijps.v3.41025
Resumen
This study was designed to explore the protective effects of ascorbic acid andwater extract of Spirulina platensis(blue green algae) on methotrexate-induced lipidperoxidation using goat liver as the lipid source. This in vitroevaluation was doneby measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione andnitric oxide content of tissue homogenates. The study reveals the lipid peroxidationinduction capacity of methotrexate, the anti-peroxidative potential of ascorbic acidand aqueous extract of S. platensison methotrexate-induced lipid peroxidation.
- Ascorbic acid
- Lipid peroxidation
- Methotrexate
- Nitric oxide
- Reducedglutathione
- Spirulina platensis
Cómo citar
Citas
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