Preparation of Chitosan Nanoparticles Loaded by Dexamethasone Sodium Phosphate Chitosan nanoparticles loaded by dexamethasone
Iranian Journal of Pharmaceutical Sciences,
Vol. 4 No. 2 (2008),
1 April 2008
,
Page 111-114
https://doi.org/10.22037/ijps.v4.41093
Abstract
Biodegradable nanoparticulate carriers, have important potential applications for administration of therapeutic molecules. Chitosan based nanoparticles have attracted a lot of attention upon their biological properties such as biodegradability, biocom-patibility and bioadhesivity. The aim of the present investigation was to describe the synthesis and characterization of novel biodegradable nanoparticles based on chitosan for encapsulation of dexamethasone sodium phosphate. To achieve this objective, ionic gelation method were used. Drug containing nanoparticles were prepared with different amounts of drug. The mean size and size distribution of nanoparticles were measured by dynamic laser light scattering. The mean particle size, varied in the range of 250-350 nm. Values of loading capacity and loading efficiency varied between 33.7%-72.2% and 44.5%-76.0% for prepared nanoparticles.
- Chitosan
- Dexamethasone
- Ionic gelation
- Nanoparticles
How to Cite
References
[2]Meclean S, Processer E, O'Malley D, Clark N,Ramtoola Z, Brayden D. Binding and uptake of biodegradable polylactide micro and nanoparticles in intestinal epithelia. Eur J Pharm Sci1998; 6:153-63.
[3]Aspden TJ, Mason JD, Jones NS. Chitosan as a nasal delivery system: The effect of chitosan solutions onin vitroand in vivo mucociliary transport rates in human turbinates and volunteers.J Pharm Sci1997; 86: 509-13.
[4]Mao HQ, Troung-le VL, Janes KA, Roy K,Wang Y, August JT, Leong KW. Chitosan-DNA nanoparticles as gene carriers: Synthesis, charac-terization and transfection efficiency.J Control Release2001; 70: 399-421.
[5]Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm Res1998; 15: 1326-31.
[6]Fernandez-Urrusuno R, Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Enhancement of nasal absorbtion of insulin using chitosan nanoparticles. Pharm Res1999; 16: 1576-81.
[7]DeCampos AM, Alonso MJ. Chitosan nanoparticles: Anew vehicle for the improvement of the delivery of drugs to the ocular surface:Application to cyclosporine A. Int J Pharm 2001;224: 116-59.
[8]Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers.J Appl Polym Sci 1997; 63: 125-32.
- Abstract Viewed: 273 times
- IJPS_Volume 4_Issue 2_Pages 111-114 Downloaded: 139 times