Evaluation of Anti-inflammatory Activity of Methanolic Extractof Solanum nigrum(Solanaceae) Anti-inflammatory effect of Solanum nigrumLinn extract
Iranian Journal of Pharmaceutical Sciences,
Vol. 5 No. 3 (2009),
1 July 2009
,
Page 151-156
https://doi.org/10.22037/ijps.v5.41210
Abstract
The methanolic extract of whole plants of Solanum nigrumL. was investigated for anti-inflammatory activity on the experimental animal models. The methanolic extract at a concentration of 100 mg.kg-1and 200 mg.kg-1, p.o.showed the significant dose dependent anti-inflammatory activity in carrageenin and egg white induced hind paw oedema in rats. Anti-inflammatory activity of the tested extract was comparable with that of the standard drug indomethacin (10 mg.kg-1) and cyproheptadine (8mg.kg-1). The results lend support to the traditional use of Solanum nigrumin the treatment of inflammatory diseases
- Anti-inflammatory activity
- Solanum nigrum
- Solanaceae
How to Cite
References
2.Tyler VE, Brady LR and Robbers JE.Pharmacognosy. 9thed. Philadelphia: Lea and Febiger, 1988.
3.Pollock JRA, Stevens R, (editors). Dictionary of Table organic compounds. Vol. 5. 4thed. London: Eyre and Spottiswoode, 1965.
4.Trease GE, Evans WC. Pharmacognosy. 12th ed.London: Baillier Tindall, 1996; pp. 344, 539.
5.Plummer, DI. An introduction to practical biochemistry. 2nded., New Delhi: Tata Magraw-Hill Publishing Co. Ltd., 1985; pp. 136, 143.
6.Winter CA, Risley EA, Nuss GW. Carrageenan induced oedema in hind paw of rat as assay for anti-inflammatory drugs.Experimental Biology Medicine1962; 111: 544-7.
7.Goth A. Effect of drugs on mast cells, Advances in Pharmacology, silivio Gartini and Parkhurst, A.shore, ed. Vol. 5. New York: Academic Press,1967; p. 68.
8.Woodson RF. Statistical methods for the analysis of biomedical data probability and mathematical statistics. Chichester: Wiley, 1987; p. 315-6.
9.Akah PA, Okogun JI, Ekpendu TO. Antioedema and analgesic activity of Diodia scandans extract in rats and mice. Phytother Res. 1993; 7: 317-9.
10.Amos S, Chindo B, Edmond I, Akah P, Wambebe C, Gamaniel K. Anti-inflammatory and anti-nociceptive effects of Ficus platyphylla extracts in mice and rats.J Herb Spice Med Plant2002;9: 47-53.
11.Di Rosa M, Giroud JP, Willoughby DA. Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine. J Pathol1971; 104:15-29.
12.Hischelmann R, Bekemeier H. Effect of catalase, peroxidase, superoxide dismutase and 10 scavengers of oxygen radicals in carrageenin oedema and in adjuvant arthritis of rats.Experientia1981; 37: 1313-4.
13.Vinegar R, Scheirber W, Hugo R. Biphasic development of carrageenan edema in rats. J Pharmacol Experiment Ther1969; 150: 328-34.
14.Crunchon P, Meacock SER. Mediators of the inflammation induced in the rat paw by carrageenin. Br J Pharmacol1971; 42: 392-402.155
- Abstract Viewed: 194 times
- IJPS_Volume 5_Issue 3_Pages 151-156 Downloaded: 111 times