Prediction of Satranidazole Solubility in Water-Polyethylene Glycol 400 Mixtures Using Extended Hildebrand Solubility Approach Prediction of satranidazole solubility
Iranian Journal of Pharmaceutical Sciences,
Vol. 7 Núm. 1 (2011),
15 January 2011
,
Página 17-24
https://doi.org/10.22037/ijps.v7.41348
Resumen
The Extended Hildebrand Solubility Parameter Approach (EHSA) is used to estimate the solubility of satranidazole in binary solvent systems. The solubility of satranidazole in various water-PEG 400 mixtures was analyzed in terms of solutesolvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility equation employs term interaction energy (W) to replace the geometric mean (δ1δ2), where δ1 and δ2 are the cohesive energy densities for the solvent and solute, respectively. The new equation provides an accurate prediction of solubility once the interaction energy ‘W’ is obtained. In this case, the energy term is regressed against a polynomial in δ1 of the binary mixture. A quartic expression of ‘W’ in terms of solvent solubility parameter was found for predicting the solubility of satranidazole in water-PEG 400 mixtures. The expression yields an error in mole fraction solubility of ~2.17%, a value approximating that of the experimentally determined solubility. The method has potential usefulness in preformulation and formulation studies during which solubility prediction is important for drug design.
- Extended hildebrand approach;
- Satranidazole;
- Solubility parameter;
- Regular solution theory.
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Citas
[2] Martin A, Wu PL. Extended hildebrand solubility approach: hydroxybenzoic acid in mixtures of dioxane and water. J Pharm Sci 1983; 72: 587-92.
[3] Thimmasetty J, Subramanyam CVS, Vishwanath BA, Sateshsabu PR. Solubility parameter estimation of celecoxib by current methods. Asian J Res Chem 2009; 2: 188-95.
[4] Subramanyam CVS, Sreenivasa RM,Venkata RJ, Gundu RP. Irregular solution behaviour of paracetamol in binary solvents. Int J Pharm 1992; 78: 17-24.
[5] Satheshbabu PR, Subrahmanyam CVS, Thimmasetty J, Manavalan R, Valliappan K.Extended hansen’s solubility approach: Meloxicam in individual solvents. Pak J Pharm Sci 2007; 20: 311-6.
[6] Martin A, Carstensen J. Extended solubility approach: solubility parameters for crystalline compounds. J Pharm Sci 1981; 70: 170-72.
[7] Martin A, Wu PL, Velasquez T. Extended hildebrand solubility approach: sulfonamides in binary and ternary solvents. J Pharm Sci 1985; 74: 277-82.
[8] Martin A, Miralles MJ. Extended hildebrand solubility approach: solubility of tolbutamide, acetohexamide and sulfisomidine in binary solvent mixtures. J Pharm Sci 2006; 71: 439-42.
[9] Mourya VK, Yadav SK, Saini TR. Solubility studies of metronidazole in binary solvent blends. Ind J Pharm Sci 1997; 59: 200-2.
[10] Martin A, Wu PL, Adjei A, Mehdizadeh M, James KC, Metzler C. Extended hildebrand solubility approach: testosterone and testosterone propionate in binary solvents. J Pharm Sci 1982; 71: 1334-40.
[11] Martin A, Wu PL, Beerbower A. Expanded solubility parameter approach I: napthalene and benzoic acid in individual solvents. J Pharm Sci 1984; 73: 179-88.
[12] Herrador MA, Gonzalez AG. Solubility prediction of caffeine in aqueous N, N-dimethyl formamide mixtures using the extended hildebrand solubility approach. Int J Pharm 1997; 156: 239-44.
[13] Martin A, Wu PL, Liron Z, Cohen S. Dependence of solute solubility parameters on solvent polarity. J Pharm Sci 1985; 74: 638-42.
[14] Martin A, Wu PL, Beerbower A. Expanded solubility parameter approach II: phydroxybenzoic acid and methyl p-hydroxybenzoate in individual solvents. J Pharm Sci 1984; 73: 188-94.
[15] Martin A, Newburger J, Adjei, A. Extended hildebrand approach: solubility of caffeine in dioxane-water mixtures. J Pharm Sci 1980; 69:659-61.
[16] Patrick JS. Martin’s physical pharmacy and pharmaceutical sciences. Philadelphia: Lippincott Williams and Wilkins, 2006; pp. 245-6, 595-6.
[17] Barton AFM. CRC handbook of solubility parameters and other cohesion parameters. New York: CRC Press, 1983; pp. 7-59, 157-85.
[18] Greenhalgh DJ, Williams AC, Timmins P, York P.Solubility parameters as predictors of miscibility in solid dispersions. J Pharm Sci 1999; 88: 1182-90.
[19] Jouyban-Gharamaleki A, Romero S, Bustamante P, Clark BJ. Multiple solubility maxima of oxolinic acid in mixed solvents and a new extension of hildebrand solubility approach. Chem Pharm Bull 2000; 48: 175-8.
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